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[Pancreatic ductal adenocarcinoma and its precursors].

Authors
  • Lüttges, J
  • Klöppel, G
Type
Published Article
Journal
Der Pathologe
Publication Date
Feb 01, 2005
Volume
26
Issue
1
Pages
12–17
Identifiers
PMID: 15630571
Source
Medline
License
Unknown

Abstract

Pancreatic ductal adenocarcinoma is the most frequent malignant pancreatic tumor. It is one of the tumors that has a particularly poor prognosis. Its morphological characteristics are: preferential localization in the head of the pancreas, ductal-glandular tumor structures combined with marked desmoplasia and CEA and MUC1 positivity. Variants of this carcinoma include adenosquamous carcinomas, undifferentiated pleomorphic carcinomas and mixed ductal-endocrine tumors. With the definition of ductal lesions as pancreatic intraepithelial neoplasia, a progression model for pancreatic ductal carcinoma has been developed and corresponding gene alterations have been detected.

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