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Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin.

Authors
  • Lorinet, A M
  • Tatemoto, K
  • Laburthe, M
  • Amiranoff, B
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Feb 07, 1989
Volume
160
Issue
3
Pages
405–407
Identifiers
PMID: 2653848
Source
Medline
License
Unknown

Abstract

Pancreastatin inhibited carbachol- but not forskolin- or GIP-stimulated insulin release from Rin m 5F cells. The inhibition induced by pancreastatin was dose-dependent, with an ED50 value of 4 nM, and reached a maximum (50% of inhibition) at 10(-7) M peptide. Pretreatment of cells with pertussis toxin abolished the inhibitory effect of pancreastatin on carbachol-induced insulin release. We suggest that pancreastatin exerts a direct inhibitory control on insulin release through a pertussis toxin-sensitive cAMP-independent pathway.

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