Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin.
- Published Article
European Journal of Pharmacology
- Publication Date
Feb 07, 1989
Pancreastatin inhibited carbachol- but not forskolin- or GIP-stimulated insulin release from Rin m 5F cells. The inhibition induced by pancreastatin was dose-dependent, with an ED50 value of 4 nM, and reached a maximum (50% of inhibition) at 10(-7) M peptide. Pretreatment of cells with pertussis toxin abolished the inhibitory effect of pancreastatin on carbachol-induced insulin release. We suggest that pancreastatin exerts a direct inhibitory control on insulin release through a pertussis toxin-sensitive cAMP-independent pathway.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2653848