Palladium-catalyzed cross-coupling of pyrrole anions with aryl chlorides, bromides, and iodides.
- Published Article
American Chemical Society
- Publication Date
Oct 28, 2004
[reaction: see text] A general method for the conversion of pyrrole anions to 2-arylpyrroles has been developed. Using a palladium precatalyst and sterically demanding 2-(dialkylphosphino)biphenyl ligands, (pyrrolyl)zinc chloride may be cross-coupled with a wide range of aryl halides, including aryl chlorides and aryl bromides, at low catalyst loadings and under mild conditions. A high degree of steric hindrance is tolerated. Certain ring-substituted pyrrole anions have also been arylated with aryl bromide substrates.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/15496079