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Palladium-catalyzed C-H bond functionalization of C6-arylpurines.

Authors
  • Guo, Hai-Ming
  • Rao, Wei-Hao
  • Niu, Hong-Ying
  • Jiang, Li-Li
  • Meng, Ge
  • Jin, Jia-Jia
  • Yang, Xi-Ning
  • Qu, Gui-Rong
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
May 21, 2011
Volume
47
Issue
19
Pages
5608–5610
Identifiers
DOI: 10.1039/c1cc11135c
PMID: 21475744
Source
Medline
License
Unknown

Abstract

A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry.

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