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Palladium-catalyzed benzannulation from alkynes and allylic compounds.

Authors
Type
Published Article
Journal
The Journal of organic chemistry
Publication Date
Volume
68
Issue
15
Pages
5961–5966
Identifiers
PMID: 12868933
Source
Medline
License
Unknown

Abstract

Various alkynes reacted with allyl tosylates in the presence of palladium catalysts, giving polysubstituted benzenes with good to high regioselectivity. Pentasubstituted and trisubstituted benzenes were readily prepared by reaction of internal alkynes and terminal alkynes, respectively. The combination of allyl alcohols and p-toluenesulfonic anhydride could be utilized in place of isolated allyl tosylates. The cyclization of diynes with allyl tosylate afforded bicyclic compounds containing an aromatic ring.

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