Affordable Access

deepdyve-link deepdyve-link
Publisher Website

PAK as a therapeutic target in gastric cancer.

Authors
  • Li, Xiaodong
  • Liu, Funan
  • Li, Feng
Type
Published Article
Journal
Expert Opinion on Therapeutic Targets
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2010
Volume
14
Issue
4
Pages
419–433
Identifiers
DOI: 10.1517/14728221003642019
PMID: 20146633
Source
Medline
License
Unknown

Abstract

PAKs play important roles in progression of many cancer types, the full mechanisms of PAKs in gastric cancer are still unclear. It seems there are different roles for two groups of PAKs in cancers. Group I PAKs play their functions mostly through their specific substrates, however, many binding partners that are independent of phosphorylation by group II PAKs were identified. Finding specific inhibitors of PAKs will help us discover the roles of PAKs and target these kinases in human gastric cancer.

Report this publication

Statistics

Seen <100 times