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Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.

Authors
  • Nc, Harper
  • R, Rillo
  • S, Jover-Gil
  • Zj, Assaf
  • Needhi Bhalla
  • Af, Dernburg
Type
Published Article
Journal
Developmental Cell
Publisher
Elsevier
Volume
21
Issue
5
Pages
934–947
Identifiers
DOI: 10.1016/j.devcel.2011.09.001
Source
UCSC Aging biomedical-ucsc
License
Unknown

Abstract

Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In C. elegans, homolog pairing and synapsis depend on pairing centers (PCs), special regions near one end of each chromosome that interact with the nuclear envelope (NE) and cytoplasmic microtubules. Here, we report that PCs are required for nuclear reorganization at the onset of meiosis. We demonstrate that PCs recruit the Polo-like kinase PLK-2 to induce NE remodeling, chromosome pairing, and synapsis. Recruitment of PLK-2 is also required to mediate a cell cycle delay and selective apoptosis of nuclei containing unsynapsed chromosomes, establishing a molecular link between these two quality control mechanisms. This work reveals unexpected functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny.

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