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Pain perception and serum beta-endorphin in trauma patients.

Authors
  • Bernstein, L
  • Garzone, P D
  • Rudy, T
  • Kramer, B
  • Stiff, D
  • Peitzman, A
Type
Published Article
Journal
Psychosomatics
Publication Date
Jan 01, 1995
Volume
36
Issue
3
Pages
276–284
Identifiers
PMID: 7638315
Source
Medline
License
Unknown

Abstract

Acute traumatic injury engenders the production of beta-endorphin (BE) and other endogenous opioids. Elevated BE concentration putatively correlates with pain perception in trauma patients. The authors examined traumatic injury severity, pain perception, and BE concentration in patients admitted to an urban trauma center. Brief rating instruments for pain and unpleasantness were administered, and blood was drawn for BE analysis in 48 trauma admissions and 33 age-, gender-, and race-matched control subjects for comparison. The authors found no correlation between severity of pain perception and BE, but a significant correlation was found between BE and patient body weight (P < 0.05), physician pain rating (P < 0.01), and Injury Severity Score (P < 0.001). The results suggest that past findings associating trauma pain perception and BE concentration are spurious.

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