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Fabrication and Characterization of Polylactic Acid Electrospun Scaffolds Modified with Multi-Walled Carbon Nanotubes and Hydroxyapatite Nanoparticles.

Authors
  • Kotrotsos, Athanasios1
  • Yiallouros, Prokopis1
  • Kostopoulos, Vassilis1, 2
  • 1 Department of Mechanical Engineering and Aeronautics, Patras University Campus, University of Patras, GR-26504 Patras, Greece. , (Greece)
  • 2 Foundation of Research and Technology, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), GR-26504 Patras, Greece. , (Greece)
Type
Published Article
Journal
Biomimetics (Basel, Switzerland)
Publication Date
Sep 02, 2020
Volume
5
Issue
3
Identifiers
DOI: 10.3390/biomimetics5030043
PMID: 32887424
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The solution electrospinning process (SEP) is a cost-effective technique in which a wide range of polymeric materials can be electrospun. Electrospun materials can also be easily modified during the solution preparation process (prior SEP). Based on this, the aim of the current work is the fabrication and nanomodification of scaffolds using SEP, and the investigation of their porosity and physical and mechanical properties. In this study, polylactic acid (PLA) was selected for scaffold fabrication, and further modified with multi-walled carbon nanotubes (MWCNTs) and hydroxyapatite (HAP) nanoparticles. After fabrication, porosity calculation and physical and mechanical characterization for all scaffold types were conducted. More precisely, the morphology of the fibers (in terms of fiber diameter), the surface properties (in terms of contact angle) and the mechanical properties under the tensile mode of the fabricated scaffolds have been investigated and further compared against pristine PLA scaffolds (without nanofillers). Finally, the scaffold with the optimal properties was proposed as the candidate material for potential future cell culturing.

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