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Paediatric brain tumours: an embryological perspective.

Authors
  • Scotting, P J
  • Thompson, S L
  • Punt, J A
  • Walker, D A
Type
Published Article
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Publication Date
May 01, 2000
Volume
16
Issue
5
Identifiers
PMID: 10883369
Source
Medline
License
Unknown

Abstract

Primitive neuroectodermal tumours are amongst the most common paediatric tumours of the central nervous system. These tumours are composed of undifferentiated cells and a variable component of more differentiated cell types. Most analysis of these tumours has focused on molecules normally found in the differentiated cells or those found in all primitive neuronal precursors. In this article we describe recent advances in understanding of the molecular processes involved in normal neurogenesis. We discuss the relevance of these data to the biology of neuronal tumours and describe strategies we and others have adopted to investigate the usefulness of molecules found in undifferentiated neuronal tissues in understanding the events which underlie oncogenesis in this tumour type.

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