Affordable Access

deepdyve-link
Publisher Website

p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy.

Authors
  • Danieli, Alberto1
  • Martens, Sascha2
  • 1 Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria. , (Austria)
  • 2 Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria [email protected] , (Austria)
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Oct 04, 2018
Volume
131
Issue
19
Identifiers
DOI: 10.1242/jcs.214304
PMID: 30287680
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The degradation of misfolded proteins is essential for cellular homeostasis. Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechanism when the UPS is overloaded. Selective autophagy mediates the degradation of harmful material by its sequestration within double-membrane organelles called autophagosomes. The selectivity of autophagic processes is mediated by cargo receptors, which link the cargo to the autophagosomal membrane. The p62 cargo receptor (SQSTM1) has a main function during the degradation of misfolded, ubiquitylated proteins by selective autophagy; here it functions to phase separate these proteins into larger condensates and tether them to the autophagosomal membrane. Recent work has given us crucial insights into the mechanism of action of the p62 cargo receptor during selective autophagy and how its activity can be integrated with the UPS. We will discuss these recent insights in the context of protein quality control and the emerging concept of cellular organization mediated by phase transitions. © 2018. Published by The Company of Biologists Ltd.

Report this publication

Statistics

Seen <100 times