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p53: traffic cop at the crossroads of DNA repair and recombination.

Authors
  • Sengupta, Sagar
  • Harris, Curtis C
Type
Published Article
Journal
Nature reviews. Molecular cell biology
Publication Date
Jan 01, 2005
Volume
6
Issue
1
Pages
44–55
Identifiers
PMID: 15688066
Source
Medline
License
Unknown

Abstract

p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.

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