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p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

Authors
  • Chen, X
  • Bargonetti, J
  • Prives, C
Type
Published Article
Journal
Cancer research
Publication Date
Oct 01, 1995
Volume
55
Issue
19
Pages
4257–4263
Identifiers
PMID: 7671232
Source
Medline
License
Unknown

Abstract

Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of under-phosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild-type p53 protein in either human or murine cells markedly increases expression of cyclin D1. The induction of cyclin D1 can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin D1 and G1 arrest defines a new cellular response to p53.

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