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P53 staining index and zonal staining patterns in actinic keratoses.

Authors
  • Javor, Sanja1, 2
  • Gasparini, Giulia1, 2, 3
  • Biatta, Chiara Maria2, 4
  • Cozzani, Emanuele5, 6
  • Cabiddu, Francesco2, 3
  • Ravetti, Jean Louis2
  • Vellone, Valerio Gaetano2, 4
  • Parodi, Aurora1, 2
  • 1 Dermatology Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. , (Italy)
  • 2 Ospedale Policlinico San Martino IRCCS, Genoa, Italy. , (Italy)
  • 3 Pathology Unit, Department of Surgical Science and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy. , (Italy)
  • 4 Department of Experimental Sciences (DIMES), University of Genoa, Genoa, Italy. , (Italy)
  • 5 Dermatology Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. [email protected] , (Italy)
  • 6 Ospedale Policlinico San Martino IRCCS, Genoa, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Archives of Dermatological Research
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
313
Issue
4
Pages
275–279
Identifiers
DOI: 10.1007/s00403-020-02104-y
PMID: 32642809
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Actinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor the histological grade of dysplasia seems valid predictors of aggressive potential of AKs. Instead, the mutational status in AKs appears to predict well the clinical course. TP53 gene mutations result in a non-functional protein resistant to degradation, thus immunohistochemical staining for p53 can suggest mutation status. Increased p53 was associated with progression from AK to squamous cell carcinoma. To investigate how the intensity of p53 staining (p53 staining index) varies according to body site, histological subtype and grade dysplasia of AKs. Secondly, we sought to investigate the distribution in the epidermal layers of non-functional p53 (zonal staining patterns). p53 staining index was greater than 50% in 90.7% of AKs. p53 staining index was significantly higher in older age (p < 0.0093) and in facial AKs compared to other body areas (p = 0.03). A significant correlation between p53 staining index and grade of dysplasia was observed (p = 0.006) and between p53 staining index and zonal p53 staining pattern (p = 0.003). No significant differences in p53 staining index among the various histological AK types were observed. No correlation between clinical and histological grade. All AKs, independently from their clinical appearance, should be treated but special attention is required for AKs on severely photodamaged skin on the face and in older patients.

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