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P53 in the impaired lungs

Authors
  • Uddin, Mohammad A.
  • Barabutis, Nektarios
Type
Published Article
Journal
DNA Repair
Publisher
Elsevier B.V.
Publication Date
Aug 19, 2020
Volume
95
Pages
102952–102952
Identifiers
DOI: 10.1016/j.dnarep.2020.102952
PMID: 32846356
PMCID: PMC7437512
Source
PubMed Central
Keywords
License
Unknown

Abstract

Our laboratory is focused on investigating the supportive role of P53 towards the maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary arterial hypertension, pneumonia and tuberculosis are respiratory pathologies, associated with dysfunctions of this endothelium defender (P53). Herein we review the evolving role of P53 towards the aforementioned inflammatory disorders, to potentially reveal new therapeutic possibilities in pulmonary disease.

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