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p53 expression, p21 expression and the apoptotic index in endometrioid endometrial adenocarcinoma.

Authors
  • Burton, J L
  • Stewart, R L
  • Heatley, M K
  • Royds, J A
  • Wells, M
Type
Published Article
Journal
Histopathology
Publication Date
Sep 01, 1999
Volume
35
Issue
3
Pages
221–229
Identifiers
PMID: 10469214
Source
Medline
License
Unknown

Abstract

Factors other than p53 are involved in the regulation of p21 expression and apoptosis in endometrioid endometrial adenocarcinomas without p53 mutations. Despite the small numbers used in this study, the data suggest a correlation between low levels of p53 immunoreactivity and apoptosis. We postulate that high levels of p53 immunoreactivity may be due to abnormal stabilization of the p53 protein. Follow-up studies are needed with a larger data set.

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