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p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart.

Authors
  • Li, Manxiang
  • Georgakopoulos, Dimitrios
  • Lu, Gang
  • Hester, Lisa
  • Kass, David A
  • Hasday, Jeffery
  • Wang, Yibin
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
May 17, 2005
Volume
111
Issue
19
Pages
2494–2502
Identifiers
PMID: 15867183
Source
Medline
License
Unknown

Abstract

Stress-activated p38 kinase is a critical regulator of inflammatory response in cardiomyocytes with significant contribution to pathological remodeling in stressed myocardium. Inhibition of p38 may represent a useful therapeutic avenue to ameliorate cardiac pathology and heart failure evolution.

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