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p21: structure and functions associated with cyclin-CDK binding.

Authors
  • Ball, K L
Type
Published Article
Journal
Progress in cell cycle research
Publication Date
Jan 01, 1997
Volume
3
Pages
125–134
Identifiers
PMID: 9552411
Source
Medline
License
Unknown

Abstract

The cyclin dependent kinase inhibitor, p21, is a multifunctional protein involved in coordinating the cellular response to negative growth signals. Induced by cellular damage under the transcriptional control of the p53 tumour suppressor protein, p21 interfaces with a number of cellular proteins involved in growth control. Although p21 has a diverse range of activities, from assembly factor to transcriptional modulator, its ability to interact with and regulate the activity of the cyclin dependent protein kinases is paramount to many of these functions.

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