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Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Authors
  • Maldonado, Paloma P.1
  • Nuno-Perez, Alvaro1
  • Kirchner, Jan H.2, 3
  • Hammock, Elizabeth4, 5
  • Gjorgjieva, Julijana2, 3
  • Lohmann, Christian1, 6
  • 1 Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands
  • 2 Max Planck Institute for Brain Research, Computation in Neural Circuits, 60438 Frankfurt am Main, Germany
  • 3 TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany
  • 4 Program in Neuroscience, The Florida State University, Tallahassee, FL 32306, USA
  • 5 Department of Psychology, The Florida State University, Tallahassee, FL 32306, USA
  • 6 Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, 1081 HV Amsterdam, the Netherlands
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Jan 25, 2021
Volume
31
Issue
2
Pages
322–333
Identifiers
DOI: 10.1016/j.cub.2020.10.028
PMID: 33157028
PMCID: PMC7846278
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Maldonado et al. uncover oxytocin’s role in developing sensory cortices. In vivo , they show that oxytocin decreases the frequency and correlations of spontaneous activity patterns in V1 by specifically activating somatostatin+ interneurons. In S1, oxytocin increases both excitation and inhibition and does not affect spontaneous activity frequency.

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