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Oxytocin Receptor Gene (OXTR) and Childhood Adversity Influence Trust.

Authors
  • Zheng, Shaofeng1
  • Masuda, Takahiko2
  • Matsunaga, Masahiro3
  • Noguchi, Yasuki4
  • Ohtsubo, Yohsuke4
  • Yamasue, Hidenori5
  • Ishii, Keiko6
  • 1 Department of Cognitive and Psychological Sciences, Graduate School of Informatics, Nagoya University, Japan. , (Japan)
  • 2 Department of Psychology, University of Alberta, Canada. , (Canada)
  • 3 Department of Health and Psychosocial Medicine, Aichi Medical University, Japan. , (Japan)
  • 4 Department of Psychology, Graduate School of Humanities, Kobe University, Japan. , (Japan)
  • 5 Department of Psychiatry, Hamamatsu University School of Medicine, Japan. , (Japan)
  • 6 Department of Cognitive and Psychological Sciences, Graduate School of Informatics, Nagoya University, Japan. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Psychoneuroendocrinology
Publication Date
Aug 18, 2020
Volume
121
Pages
104840–104840
Identifiers
DOI: 10.1016/j.psyneuen.2020.104840
PMID: 32866773
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Early-life environments have been associated with various social behaviors, including trust, in late adolescence and adulthood. Given that the oxytocin receptor gene polymorphism (OXTR rs53576) moderates the impact of childhood experience on social behaviors, in the present study, we examined the main effect of childhood adversity through a self-report measure and its interactions with OXTR rs53576 on general trust among 203 Japanese and 200 European Canadian undergraduate students. After controlling for the effect of culture, the results indicated that childhood adversity had a negative association with general trust, and that OXTR rs53576 moderated the impact of childhood adversity on general trust. Specifically, the negative association between childhood adversity and general trust is only significant among homozygote A-allele carriers. These findings demonstrated that OXTR rs53576 moderated the relations between childhood experiences and social functioning in early adulthood. Copyright © 2020 Elsevier Ltd. All rights reserved.

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