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Oxygen transport in a permeable model of abdominal aortic aneurysm.

Authors
  • Zakerzadeh, Rana1
  • Cupac, Tanja1
  • Durka, Michael2
  • 1 Department of Biomedical Engineering, Rangos School of Health Sciences, Duquesne University, Pittsburgh, PA, USA.
  • 2 Department of Mechanical Engineering & Material Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Type
Published Article
Journal
Computer Methods in Biomechanics & Biomedical Engineering
Publisher
Informa UK (Taylor & Francis)
Publication Date
Feb 01, 2021
Volume
24
Issue
2
Pages
215–229
Identifiers
DOI: 10.1080/10255842.2020.1821193
PMID: 32960082
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This paper reports on modelling and simulation of the coupled mass and momentum transport through the arterial lumen and the porous arterial wall of an abdominal aortic aneurysm (AAA). The effect of porous structure and intramural flow, which is usually neglected, is essential to quantify the oxygen concentration in the aneurysmal wall and will be addressed in this work via a novel coupled fluid-porous structure-mass transport model for AAA. The computational solver provides a prediction of the filtration velocity and oxygen concentration in the artery and further simulations are used to investigate the relation between the wall oxygen concentration and permeability. The results demonstrate the essential coupling between blood and filtration flow and specifically how their interactions affect oxygen transport.

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