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Oxygen radical stress in vascular disease: the role of endothelial nitric oxide synthase.

Authors
  • Stroes, E S
  • van Faassen, E E
  • van Londen, G J
  • Rabelink, T J
Type
Published Article
Journal
Journal of Cardiovascular Pharmacology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 1998
Volume
32 Suppl 3
Identifiers
PMID: 9883742
Source
Medline
License
Unknown

Abstract

Impaired nitric oxide (NO) activity in proatherosclerotic states has been suggested to be caused mainly by increased degradation of NO by oxygen radicals. In recent years, endothelial NO synthase has been identified as a system that contributes to oxygen radical stress under pathophysiologic conditions. We discuss the origin of NO synthase-derived superoxide production, as well as possibilities to modulate (pathologic) shifts in NO/superoxide production by endothelial NO synthase.

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