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Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process.

Authors
  • Benchenane, Karim
  • Berezowski, Vincent
  • Fernández-Monreal, Mónica
  • Brillault, Julien
  • Valable, Samuel
  • Dehouck, Marie-Pierre
  • Cecchelli, Roméo
  • Vivien, Denis
  • Touzani, Omar
  • Ali, Carine
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
May 01, 2005
Volume
36
Issue
5
Pages
1065–1070
Identifiers
PMID: 15817895
Source
Medline
License
Unknown

Abstract

We evidence 2 different mechanisms through which vascular tPA can reach the brain parenchyma, depending on the state of the BBB. As discussed, these data show the importance of taking the side effects of blood-derived tPA into account and offer a basis to improve the current thrombolytic strategy.

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