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Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemic insult in hemorrhagic shock.

Authors
  • Dunham, C M
  • Siegel, J H
  • Weireter, L
  • Fabian, M
  • Goodarzi, S
  • Guadalupi, P
  • Gettings, L
  • Linberg, S E
  • Vary, T C
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Feb 01, 1991
Volume
19
Issue
2
Pages
231–243
Identifiers
PMID: 1989759
Source
Medline
License
Unknown

Abstract

Of the single-variable predictors, BE shows the highest explained variability. However, a combined prediction from both lactate and BE appears superior to the use of either alone. Using this regression to compute the oxygen debt, it is possible to estimate accurately the actual level of oxygen debt from the BE and lactate values obtained during hemorrhagic hypovolemia. From serial determinations over time of the increase in these biochemical variables above the oxygen debt baseline, it is possible to estimate the rate of oxygen debt accumulation and the time remaining until the LD50 will be reached as indicators of the severity of the total body ischemia resulting from hemorrhagic shock.

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