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Oxime ligation on the surface of mesoporous silica nanoparticles.

Authors
  • Ferris, Daniel P
  • McGonigal, Paul R
  • Witus, Leah S
  • Kawaji, Takatoshi
  • Algaradah, Mohammed M
  • Alnajadah, Ahmed R
  • Nassar, Majed S
  • Stoddart, J Fraser
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
May 01, 2015
Volume
17
Issue
9
Pages
2146–2149
Identifiers
DOI: 10.1021/acs.orglett.5b00740
PMID: 25894019
Source
Medline
License
Unknown

Abstract

A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.

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