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Oxidized products of linoleic acid stimulate adrenal steroidogenesis.

Authors
  • Goodfriend, T L1
  • Ball, D L
  • Raff, H
  • Bruder, E D
  • Gardner, H W
  • Spiteller, G
  • 1 Wm. S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. [email protected]
Type
Published Article
Journal
Endocrine research
Publication Date
Nov 01, 2002
Volume
28
Issue
4
Pages
325–330
Identifiers
PMID: 12530633
Source
Medline
License
Unknown

Abstract

Adrenal steroidogenesis is under complex control, and clinical observations suggest that not all regulators have been identified. We postulated that fatty acid oxidation products found in the diet or formed in the body could affect steroidogenesis. Linoleic acid is a prominent constituent of animal fat and is readily oxidized. We found that several products of linoleic acid oxidation affect production of aldosterone and corticosterone by isolated cells from rat adrenals. We characterized one linoleic acid derivative by gas chromatography/mass spectrometry. It is 12,13-epoxy-9-oxo-10(trans)-octadecenoic acid ("EKODE"). At concentrations between 1 and 30 microM, EKODE stimulated production of aldosterone by zona glomerulosa cells, but at concentrations above 50 microM, it was inhibitory. In zona fasciculata cells, EKODE stimulated corticosterone production at concentrations of 5 microM or greater, and there was no evidence of inhibition at high concentrations. Stimulation of steroidogenesis was observed after 15 min of incubation and continued for at least 2 hrs. The potential relevance of our findings to the hypertension of obesity is discussed.

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