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Oxidative Stress in Preeclampsia and Placental Diseases.

Authors
  • 1 Institut National de la Santé Et de la Recherche Médicale, U1016, Institut Cochin, 75014 Paris, France. [email protected] , (France)
  • 2 Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France. [email protected] , (France)
  • 3 Département Développement, Génétique, Neurobiologie, Reproduction et Vieillissement, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. [email protected] , (France)
  • 4 Département Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France. [email protected] , (France)
  • 5 Institut National de la Santé Et de la Recherche Médicale, U1016, Institut Cochin, 75014 Paris, France. [email protected] , (France)
  • 6 Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France. [email protected] , (France)
  • 7 Département Développement, Génétique, Neurobiologie, Reproduction et Vieillissement, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. [email protected] , (France)
  • 8 Département Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France. [email protected] , (France)
  • 9 Institut National de la Santé Et de la Recherche Médicale, U1016, Institut Cochin, 75014 Paris, France. [email protected] , (France)
  • 10 Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France. [email protected] , (France)
  • 11 Département Développement, Génétique, Neurobiologie, Reproduction et Vieillissement, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. [email protected] , (France)
  • 12 Département Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France. [email protected] , (France)
  • 13 Institut National de la Santé Et de la Recherche Médicale, U1016, Institut Cochin, 75014 Paris, France. [email protected] , (France)
  • 14 Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France. [email protected] , (France)
  • 15 Département Développement, Génétique, Neurobiologie, Reproduction et Vieillissement, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. [email protected] , (France)
  • 16 Département Hospitalo-Universitaire Risques et Grossesse, PRES Sorbonne, 75014 Paris, France. [email protected] , (France)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
May 17, 2018
Volume
19
Issue
5
Identifiers
DOI: 10.3390/ijms19051496
PMID: 29772777
Source
Medline
Keywords
License
Unknown

Abstract

Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.

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