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Oxidative Stress and Neurotoxicity of Cadmium and Zinc on Artemia franciscana.

Authors
  • Kukavica, Biljana1
  • Davidović-Plavšić, Biljana2
  • Savić, Ana3
  • Dmitrović, Dejan4
  • Šukalo, Goran4
  • Đurić-Savić, Sandra5
  • Vučić, Goran6
  • 1 Departmant of Biology, Faculty of Natural Sciences and Mathematics, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. [email protected]. , (Bosnia & Herzegovina)
  • 2 Departmant of Chemistry, Faculty of Natural Sciences and Mathematics, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 3 Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Niš, Serbia. , (Serbia)
  • 4 Departmant of Biology, Faculty of Natural Sciences and Mathematics, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 5 Miloš Dujić Elementary School, Čelinac, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 6 Faculty of Technology, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
Type
Published Article
Journal
Biological Trace Element Research
Publisher
Springer-Verlag
Publication Date
May 01, 2023
Volume
201
Issue
5
Pages
2636–2649
Identifiers
DOI: 10.1007/s12011-022-03352-x
PMID: 35831694
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Despite not being redox-active metals, Cd and Zn can disrupt cellular redox homeostasis by acting pro-oxidatively. The aim of this study was to examine the effects of exposure to Zn (14 and 72 mg/L) and Cd (7.7 and 77 mg/L) for 24 and 48 h on oxidative and antioxidative parameters and the activity of glutathione-S-transferase in Artemia franciscana tissue. In addition, the neurotoxicity of the metals was examined by determining the activity of acetylcholinesterase (AChE). In A. franciscana tissue, Cd (0.0026 ± 0.0001 mg/L) was detected only after 48 h of exposure to 77 mg/L Cd. After 24 h, the 14- and 72-mg/L Zn treatments resulted in significant increases in the Zn concentration (0.54 ± 0.026 mg/L (p < 0.01) and 0.68 ± 0.035 (p < 0.0001), respectively) in A. franciscana tissue compared with the control level, and significant increases were also detected after 48 h (0.59 ± 0.02 (p < 0.0001) and 0.79 ± 0.015 (p < 0.0001), respectively). The malondialdehyde (MDA) concentration in the metal-treated samples was increased after 24 h of exposure, whereas after 48 h, an increase in the MDA concentration was detected only with 7.7. mg/L Cd. A significant increase in the H2O2 concentration after 24 h was measured only after treatment with 72 mg/L Zn. The treatment with 7.7 mg/L Cd for 24 h induced a significant increase in the AChE activity, whereas 48 h of treatment with 77 mg/L Cd and 14 mg/L Zn significantly inhibited AChE. The results indicate that lipid peroxidation resulting from metal toxicity may constitute the basis of neurotoxicity. © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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