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Oxidative stress and frailty: A systematic review and synthesis of the best evidence.

Authors
  • Soysal, Pinar1
  • Isik, Ahmet Turan2
  • Carvalho, Andre F3
  • Fernandes, Brisa S4
  • Solmi, Marco5
  • Schofield, Patricia6
  • Veronese, Nicola7
  • Stubbs, Brendon8
  • 1 Kayseri Education and Research Hospital, Geriatric Center, Kayseri, Turkey; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 2 Center for Aging Brain and Dementia, Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 3 Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 4 Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia; Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 5 Department of Neurosciences, University of Padova, Padova, Italy; National Health Care System, Padova Local Unit ULSS 17, Italy; Institute for Clinical Research and Education in Medicine, I.R.E.M., Padua, Italy; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 6 Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom.
  • 7 Institute for Clinical Research and Education in Medicine, I.R.E.M., Padua, Italy; Geriatrics Division, Department of Medicine-DIMED, University of Padova, Italy.
  • 8 Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom; Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy; Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, United Kingdom. Electronic address: [email protected]
Type
Published Article
Journal
Maturitas
Publication Date
May 2017
Volume
99
Pages
66–72
Identifiers
DOI: 10.1016/j.maturitas.2017.01.006
PMID: 28364871
Source
Medline
Keywords
License
Unknown

Abstract

Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters. However, due to the cross-sectional design, it is not possible to disentangle the directionality of the relationships observed. Thus, future high-quality and in particular longitudinal research is required to confirm or refute these relationships and to further elucidate pathophysiological mechanisms.

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