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Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia.

Authors
  • Bailey, Damian M1
  • Rimoldi, Stefano F2
  • Rexhaj, Emrush2
  • Pratali, Lorenza3
  • Salinas Salmòn, Carlos4
  • Villena, Mercedes4
  • McEneny, Jane5
  • Young, Ian S5
  • Nicod, Pascal6
  • Allemann, Yves2
  • Scherrer, Urs7
  • Sartori, Claudio8
  • 1 Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Wales; Sondes Moléculaires en Biologie et Stress Oxydant, Institut de Chimie Radicalaire, Centre National de la Recherche Scientifique UMR 7273, Aix-Marseille University, France. Electronic address: [email protected] , (France)
  • 2 Department of Cardiology, University Hospital of Bern, Bern, Switzerland. , (Switzerland)
  • 3 Institute of Clinical Physiology, CNR, Pisa, Italy. , (Italy)
  • 4 Instituto Boliviano de Biologia de Altura, La Paz, Bolivia. , (Bolivia)
  • 5 Centre for Clinical and Population Sciences, Queen's University Belfast, Belfast, Northern Ireland. , (Ireland)
  • 6 Botnar Center for Clinical Research, Hirslanden Group, Lausanne, Switzerland. , (Switzerland)
  • 7 Department of Cardiology, University Hospital of Bern, Bern, Switzerland; Botnar Center for Clinical Research, Hirslanden Group, Lausanne, Switzerland; Facultad de Ciencias, Departamento de Biología, Universidad de Tarapacá, Arica, Chile. , (Switzerland)
  • 8 Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. , (Switzerland)
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
Feb 01, 2013
Volume
143
Issue
2
Pages
444–451
Identifiers
DOI: 10.1378/chest.12-0728
PMID: 22922469
Source
Medline
License
Unknown

Abstract

Healthy highlanders display a moderate, sustained elevation in oxidative-nitrosative stress that, unlike the equivalent increase evoked by acute hypoxia in healthy lowlanders, failed to affect vascular function. Its more marked elevation in patients with CMS may contribute to systemic vascular dysfunction.

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