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Oxidative metabolism of mescaline in the central nervous system—IV

Authors
  • Seiler, Nikolaus
  • Demisch, Lothar
Type
Published Article
Journal
Biochemical Pharmacology
Publisher
Elsevier
Publication Date
Jan 01, 1974
Accepted Date
Jun 25, 1973
Volume
23
Issue
2
Pages
273–287
Identifiers
DOI: 10.1016/0006-2952(74)90418-3
Source
Elsevier
Keywords
License
Unknown

Abstract

Metabolic rates of mescaline (3,4,5-trimethoxy-β-phenylethylamine) and of its non-hallucinogenic isomer, 2,3,4-trimethoxy-β-phenylethylamine were studied in whole and in different areas of mouse brain in vivo. The effects of Pargyline and of Probenecid on the concentrations of the amines and their corresponding metabolites, together with the results obtained from intraventricular injections of mescaline suggested the formation of the trimethoxyphenylacetic acids in the brain. The metabolic differences between mescaline and 2,3,4-trimethoxy-β-phenylethylamine are discussed in terms of possible implications of metabolic parameters with psychotomimetic activity.

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