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Oxidative carbonylation of <i>N</i>-protected indoles by Rh(iii)-zeolites

Authors
  • Van Minnebruggen, Sam; 133976;
  • Marquez, Carlos;
  • Krasniqi, Besir;
  • Janssens, Kwinten; 124871;
  • Van Velthoven, Niels; 112299;
  • Vercammen, Jannick; 116990;
  • De Soete, Benoit;
  • Bugaev, Aram;
  • De Vos, Dirk; 12869;
Publication Date
Feb 21, 2023
Source
Lirias
Keywords
License
Unknown
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Abstract

The oxidative carbonylation of N-protected indoles was investigated to directly synthesize indole-3-carboxylic acids. Using Rh(III)-zeolites as heterogeneous catalysts, the single-site Rh-species reach unprecedented activities (>100 turnovers), while the metal is readily recovered after reaction. X-ray absorption spectroscopy (XAS) provided evidence for site-isolation of Rh(III) species on the zeolite. / status: published

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