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Oxidation of polyunsaturated fatty acids to produce lipid mediators.

Authors
  • Christie, William W1
  • Harwood, John L2
  • 1 James Hutton Institute, Invergowrie, Dundee, Scotland DD2 5DA, U.K.
  • 2 School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, U.K.
Type
Published Article
Journal
Essays in biochemistry
Publication Date
Sep 23, 2020
Volume
64
Issue
3
Pages
401–421
Identifiers
DOI: 10.1042/EBC20190082
PMID: 32618335
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The chemistry, biochemistry, pharmacology and molecular biology of oxylipins (defined as a family of oxygenated natural products that are formed from unsaturated fatty acids by pathways involving at least one step of dioxygen-dependent oxidation) are complex and occasionally contradictory subjects that continue to develop at an extraordinarily rapid rate. The term includes docosanoids (e.g. protectins, resolvins and maresins, or specialized pro-resolving mediators), eicosanoids and octadecanoids and plant oxylipins, which are derived from either the omega-6 (n-6) or the omega-3 (n-3) families of polyunsaturated fatty acids. For example, the term eicosanoid is used to embrace those biologically active lipid mediators that are derived from C20 fatty acids, and include prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and related oxygenated derivatives. The key enzymes for the production of prostanoids are prostaglandin endoperoxide H synthases (cyclo-oxygenases), while lipoxygenases and oxidases of the cytochrome P450 family produce numerous other metabolites. In plants, the lipoxygenase pathway from C18 polyunsaturated fatty acids yields a variety of important products, especially the jasmonates, which have some comparable structural features and functions. Related oxylipins are produced by non-enzymic means (isoprostanes), while fatty acid esters of hydroxy fatty acids (FAHFA) are now being considered together with the oxylipins from a functional perspective. In all kingdoms of life, oxylipins usually act as lipid mediators through specific receptors, have short half-lives and have functions in innumerable biological contexts. © 2020 The Author(s).

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