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Oxidation of H2S in mammalian cells and mitochondria

Authors
  • Abou-Hamdan, Abbas
  • Guedouari-Bounihi, Hala
  • Lenoir, Véronique
  • Andriamihaja, Mireille
  • Blachier, François
  • Frédéric Bouillaud
Type
Published Article
Journal
G Protein Coupled Receptors - Structure
Publisher
Elsevier BV
Publication Date
Jul 15, 2015
Volume
554
Pages
28–201
Identifiers
DOI: 10.1016/bs.mie.2014.11.042
PMID: 25725524
Source
USPC - SET - SVS
License
White

Abstract

Hydrogen sulfide (H2S) is the third gasotransmitter described in mammals. These gasotransmitters (H2S, CO, and NO) are small molecules able to diffuse freely across membranes and thus susceptible to reach easily intracellular targets, one of which is the respiratory enzyme cytochrome oxidase subject to complete inhibition by low micromolar concentrations of these gases. However in contrast to NO or CO, H2S can be metabolized by a sulfide quinone reductase feeding the mitochondrial respiratory chain with the hydrogen atoms of sulfide. Sulfide is thus a two-sided molecule: substrate or poison according to the concentration. The aim of this chapter is to present a mean to monitor sulfide oxidation by isolated mitochondria or cells and to summarize how the properties of this amazing couple (mitochondria and sulfide) translate into practical and conceptual consequences.

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