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OXIDATION OF CARBON-14-LABELED ENDOGENOUS LIPIDS BY ISOLATED PERFUSED RAT HEART.

Authors
  • SHIPP, J C
  • THOMAS, J M
  • CREVASSE, L
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jan 24, 1964
Volume
143
Issue
3604
Pages
371–373
Identifiers
PMID: 14074856
Source
Medline
Keywords
License
Unknown

Abstract

Lipids of the rat heart were labeled with carbon-14 in vivo. The production of C(14)O(2) during the subsequent perfusion of these glycogen-depleted hearts with buffer, but without added substrate, provided direct evidence of the oxidation of endogenous heart lipids. The net decrease in phospholipid content alone could account for 75 percent of the total metabolic CO(2) formed.

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