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The oxetane conformational lock of paclitaxel: structural analysis of D-secopaclitaxel.

Authors
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
9
Issue
20
Pages
3041–3046
Identifiers
PMID: 10571172
Source
Medline

Abstract

Analysis of the 1H NMR data of paclitaxel in comparison with its oxetane ring-opened analogue D-secopaclitaxel suggests that the oxetane moiety (D-ring) of paclitaxel serves as a conformational lock for the diterpene moiety and the C13 side chain.

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