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Oxaliplatin: a review of its use in the management of metastatic colorectal cancer.

Authors
Type
Published Article
Journal
Drugs & aging
Publication Date
Volume
14
Issue
6
Pages
459–475
Identifiers
PMID: 10408744
Source
Medline
License
Unknown

Abstract

oxaliplatin is a promising treatment option for patients with metastatic colorectal cancer. It appears to be particularly advantageous (in terms of response rate and duration of progression-free survival) when used in combination with fluorouracil/calcium folinate as both a first- and second-line option, although preliminary studies have failed to show any survival advantage over fluorouracil/calcium folinate alone. Promising results have been found in studies of the drug as monotherapy, and oxaliplatin may also prove useful in the neoadjuvant setting in patients with unresectable liver metastases; however, data are limited at present.

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