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Overview of significant examples of electrochemical sensor arrays designed for detection of nitric oxide and relevant species in a biological environment.

Authors
Type
Published Article
Journal
Analytical and Bioanalytical Chemistry
1618-2650
Publisher
Springer-Verlag
Publication Date
Volume
405
Issue
11
Pages
3475–3488
Identifiers
DOI: 10.1007/s00216-012-6671-6
PMID: 23334219
Source
Medline
License
Unknown

Abstract

Ultramicroelectrode sensor arrays in which each electrode, or groups of electrodes, are individually addressable are of particular interest for detection of several species concomitantly, by using specific sensing chemistry for each analyte, or for mapping of one analyte to achieve spatio-temporal analysis. Microfabrication technology, for example photolitography, is usually used for fabrication of these arrays. The most widespread geometries produced by photolithography are thin-film microdisc electrode arrays with different electrode distributions (square, hexagonal, or random). In this paper we review different electrochemical sensor arrays developed to monitor, in vivo, NO levels produced by cultured cells or sliced tissues. Simultaneous detection of NO and analytes interacting with or released at the same time as NO is also discussed.

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