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An Overview of Natural Plant Products in the Treatment of Hepatocellular Carcinoma.

Authors
  • Rawat, Divya1
  • Shrivastava, Somi1
  • Naik, Rayees A2
  • Chhonker, Saurabh K1
  • Mehrotra, Aditi3
  • Koiri, Raj K1
  • 1 Biochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar-470003, Madhya Pradesh, India. , (India)
  • 2 Insect Immunity Lab, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar-470003 (M.P.), India. , (India)
  • 3 Biochemistry & Molecular Biology Lab, Department of Zoology, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India. , (India)
Type
Published Article
Journal
Anti-cancer agents in medicinal chemistry
Publication Date
Jan 01, 2018
Volume
18
Issue
13
Pages
1838–1859
Identifiers
DOI: 10.2174/1871520618666180604085612
PMID: 29866017
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Liver cancer is the fifth most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Among the liver cancers, hepatocellular carcinoma has been reported to be responsible for 85-90% of primary liver cancer and it is the second most common cause of cancer mortality with 700,000 deaths documented annually. The major risk factors of HCC include chronic infections with the hepatitis B (HBV) or hepatitis C (HCV) virus, chronic liver diseases, alcoholism as well as dietary carcinogens, such as aflatoxins. Highest incidence rates are estimated to occur in Asia and Africa. The effectiveness of current man-made agents in treating chronic liver disease is not satisfactory and they have uninvited side effects. Herbal medicines are extensively used all over the world; however, there is still a vast gap in their acceptance by the scientific community. Plants are rich in secondary metabolites and phytochemicals obtained from both, dietary and non-dietary sources. Natural plant products are potent therapeutic as well as chemopreventive agents for numerous chronic diseases like cardiovascular, metabolic, neurodegenerative and neoplastic diseases. Dietary phytochemicals such as curcumin, resveratrol, quercetin, silibinin, N-trans-feruloyl octopamine, lycopene, emodin, caffeine, urolithin A and Phloretin have been found to be useful for the treatment of HCC and other diseases. According to recent reports 60% of the anticancer medication in current use has been obtained from natural sources. Thus, derivatives from plants have played an essential role in cancer prevention due to their pleiotropic abilities to scavenge free radicals, inhibit cell growth and induce apoptosis. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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