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Overview of Cadmium Thyroid Disrupting Effects and Mechanisms.

Authors
  • Buha, Aleksandra1
  • Matovic, Vesna2
  • Antonijevic, Biljana3
  • Bulat, Zorica4
  • Curcic, Marijana5
  • Renieri, Elisavet A6
  • Tsatsakis, Aristidis M7
  • Schweitzer, Amie8
  • Wallace, David9
  • 1 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia. [email protected] , (Serbia)
  • 2 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia. [email protected] , (Serbia)
  • 3 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia. [email protected] , (Serbia)
  • 4 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia. [email protected] , (Serbia)
  • 5 Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia. [email protected] , (Serbia)
  • 6 Laboratory of Toxicology, University of Crete, Medical School, 71003 Crete, Greece. [email protected] , (Greece)
  • 7 Laboratory of Toxicology, University of Crete, Medical School, 71003 Crete, Greece. [email protected] , (Greece)
  • 8 School of Biomedical Science, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA. [email protected]
  • 9 School of Biomedical Science, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA. [email protected]
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
May 17, 2018
Volume
19
Issue
5
Identifiers
DOI: 10.3390/ijms19051501
PMID: 29772829
Source
Medline
Keywords
License
Unknown

Abstract

Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

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