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Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson’s disease

Authors
  • Schwartz, Frank1
  • Tahmasian, Masoud2
  • Maier, Franziska1, 3
  • Rochhausen, Luisa1
  • Schnorrenberg, Kim L.1
  • Samea, Fateme4
  • Seemiller, Joseph5
  • Zarei, Mojtaba2
  • Sorg, Christian6, 7, 8
  • Drzezga, Alexander9
  • Timmermann, Lars1, 3
  • Meyer, Thomas D.10
  • van Eimeren, Thilo1, 9
  • Eggers, Carsten1, 3
  • 1 University Hospital Cologne, Department of Neurology, Cologne, Germany , Cologne (Germany)
  • 2 Shahid Beheshti University, Institute of Medical Science and Technology, Tehran, Iran , Tehran (Iran)
  • 3 University Hospital Marburg, Department of Neurology, Marburg, Germany , Marburg (Germany)
  • 4 Shahid Beheshti University, Institute for Cognitive and Brain Sciences, Tehran, Iran , Tehran (Iran)
  • 5 Geisinger Commonwealth School of Medicine, Scranton, PA, USA , Scranton (United States)
  • 6 Technische Universität München, Departments of Neuroradiology, Klinikum rechts der Isar, Munich, Germany , Munich (Germany)
  • 7 Technische Universität München, TUM-Neuroimaging Center (TUM-NIC), Munich, Germany , Munich (Germany)
  • 8 Technische Universität München, Department of Psychiatry, Munich, Germany , Munich (Germany)
  • 9 University Hospital Cologne, Department of Nuclear Medicine, Cologne, Germany , Cologne (Germany)
  • 10 University of Texas Health Science Center, McGovern Medical School, Department of Psychiatry and Behavioral Sciences, Houston, TX, USA , Houston (United States)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Jan 10, 2018
Volume
13
Issue
1
Pages
241–254
Identifiers
DOI: 10.1007/s11682-017-9812-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

Impulsivity and hypomania are common non-motor features in Parkinson’s disease (PD). The aim of this study was to find the overlapping and distinct neural correlates of these symptoms in PD. Symptoms of impulsivity and hypomania were assessed in 24 PD patients using the Barratt Impulsiveness Scale (BIS-11) and Self-Report Manic Inventory (SRMI), respectively. In addition, fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for each individual was performed. We conducted two separate multiple regression analyses for BIS-11 and SRMI scores with FDG-PET data to identify the brain regions that are associated with both impulsivity and hypomania scores, as well as those exclusive to each symptom. Then, seed-based functional connectivity analyses on healthy subjects identified the areas connected to each of the exclusive regions and the overlapping region, used as seeds. We observed a positive association between BIS-11 and SRMI scores and neural metabolism only in the prefrontal areas. Conjunction analysis revealed an overlapping region in the middle frontal gyrus. Regions exclusive to impulsivity were found in the medial part of the right superior frontal gyrus and regions exclusive to hypomania were in the right superior frontal gyrus, right precentral gyrus and right paracentral lobule. Connectivity patterns of seeds exclusively related to impulsivity were different from those for hypomania in healthy brains. These results provide evidence of both overlapping and distinct regions linked with impulsivity and hypomania scores in PD. The exclusive regions for each characteristic are connected to specific intrinsic functional networks.

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