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Overexpression of miR-21 and miR-122 in preeclamptic placentas.

Authors
  • Lasabová, Zora1
  • Vazan, Martin1
  • Zibolenova, Jana2
  • Svecova, Iveta3
  • 1 Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia.
  • 2 Department of Public Health, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia.
  • 3 Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia.
Type
Published Article
Journal
Neuro endocrinology letters
Publication Date
December 2015
Volume
36
Issue
7
Pages
695–699
Identifiers
PMID: 26859593
Source
Medline
License
Unknown

Abstract

The apoptosis-associated miRNAs miR-21 and miR-122 are dysregulated in the term preeclamptic placentas. The increased miRNA expression suggest the downregulation of potential targets mRNAs, which can contribute to the pathogenesis of preeclampsia. The identification of their targets in placenta will improve our understanding of their role in preeclampsia.

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