Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

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Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

Authors
  • Sarogni, Patrizia
  • Palumbo, Orazio
  • Servadio, Adele
  • Astigiano, Simonetta
  • D’Alessio, Barbara
  • Gatti, Veronica
  • Cukrov, Dubravka
  • Baldari, Silvia
  • Pallotta, Maria Michela
  • Aretini, Paolo
  • Dell’Orletta, Felice
  • Soddu, Silvia
  • Carella, Massimo
  • Toietta, Gabriele
  • Barbieri, Ottavia
  • Fontanini, Gabriella
  • Musio, Antonio
Type
Published Article
Journal
Journal of Experimental & Clinical Cancer Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 03, 2019
Volume
38
Issue
1
Identifiers
DOI: 10.1186/s13046-019-1116-0
Source
MyScienceWork
Keywords
License
Green

Abstract

Background: Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a large protein ring that binds DNA strands by encircling them. In addition to this central role in chromosome segregation, cohesin is also needed for DNA repair, gene transcription regulation and chromatin architecture. Though mutations in both cohesin and cohesin-regulator genes have been identified in many human cancers, the contribution of cohesin to cancer development is still under debate.

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