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Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Authors
  • Bernstein, Kenneth E1
  • Khan, Zakir1
  • Giani, Jorge F1
  • Zhao, Tuantuan1
  • Eriguchi, Masahiro1
  • Bernstein, Ellen A1
  • Gonzalez-Villalobos, Romer A1
  • Shen, Xiao Z1
  • 1 Department of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Type
Published Article
Journal
F1000Research
Publisher
"F1000 Research, Ltd."
Publication Date
Jan 01, 2016
Volume
5
Identifiers
DOI: 10.12688/f1000research.7508.1
PMID: 27018193
Source
Medline
Keywords
License
Unknown

Abstract

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

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