Affordable Access

Access to the full text

Overexpression of ACE in Myeloid Cells Increases Immune Effectiveness and Leads to a New Way of Considering Inflammation in Acute and Chronic Diseases

Authors
  • Veiras, Luciana C.1
  • Cao, DuoYao1
  • Saito, Suguru1
  • Peng, Zhenzi1
  • Bernstein, Ellen A.1
  • Shen, Justin Z. Y.1
  • Koronyo-Hamaoui, Maya1, 2
  • Okwan-Duodu, Derick1, 3
  • Giani, Jorge F.1, 3
  • Khan, Zakir1, 3
  • Bernstein, Kenneth E.1, 3
  • 1 Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA , Los Angeles (United States)
  • 2 Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA , Los Angeles (United States)
  • 3 Cedars-Sinai Medical Center, Davis Research Building, Rm 2021, 110 N George Burns Rd., Los Angeles, CA, 90048, USA , Los Angeles (United States)
Type
Published Article
Journal
Current Hypertension Reports
Publisher
Springer-Verlag
Publication Date
Jan 08, 2020
Volume
22
Issue
1
Identifiers
DOI: 10.1007/s11906-019-1008-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewTo review recent studies exploring how myeloid cell overexpression of angiotensin-converting enzyme (ACE) affects the immune response and to formulate an approach for considering the effectiveness of inflammation in cardiovascular diseaseRecent FindingsWhile it is widely appreciated that the renin-angiotensin system affects aspects of inflammation through the action of angiotensin II, new studies reveal a previously unknown role of ACE in myeloid cell biology. This was apparent from analysis of two mouse lines genetically modified to overexpress ACE in monocytes/macrophages or neutrophils. Cells overexpressing ACE demonstrated an increased immune response. For example, mice with increased macrophage ACE expression have increased resistance to melanoma, methicillin-resistant Staphylococcus aureus, a mouse model of Alzheimer’s disease, and ApoE-knockout-induced atherosclerosis. These data indicate the profound effect of increasing myeloid cell function. Further, they suggest that an appropriate way to evaluate inflammation in both acute and chronic diseases is to ask whether the inflammatory infiltrate is sufficient to eliminate the immune challenge.SummaryThe expression of ACE by myeloid cells induces a heightened immune response by these cells. The overexpression of ACE is associated with immune function beyond that possible by wild type (WT) myeloid cells. A heightened immune response effectively resolves disease in a variety of acute and chronic models of disease including models of Alzheimer’s disease and atherosclerosis.

Report this publication

Statistics

Seen <100 times