Overcoming pH defenses on the skin to establish infections.
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Department of Veterans Affairs, Eastern Colorado Healthcare System, Aurora, Colorado, United States of America.
- Published Article
Public Library of Science
- Publication Date
May 01, 2022
Skin health is influenced by the composition and integrity of the skin barrier. The healthy skin surface is an acidic, hypertonic, proteinaceous, and lipid-rich environment that microorganisms must adapt to for survival, and disruption of this environment can result in dysbiosis and increase risk for infectious diseases. This work provides a brief overview of skin barrier function and skin surface composition from the perspective of how the most common skin pathogen, Staphylococcus aureus, combats acid stress. Advancements in replicating this environment in the laboratory setting for the study of S. aureus pathogenesis on the skin, as well as future directions in this field, are also discussed.
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This record was last updated on 12/19/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/35617212