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Ovarian yolk sac tumor with epithelial tumor component in a postmenopausal woman - case report and literature review

Authors
  • Ahn, Hyein1
  • Oh, Mee-Hye1
  • Cho, Hyun Deuk1
  • Lee, Ji-Hye1
  • Lee, Hyun Ju1
  • Jeon, Seob2
  • Jang, Si-Hyong1
  • 1 Department of Pathology, College of Medicine, Soonchunhyang University, Cheonan, Korea
  • 2 Departments of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Cheonan, Korea
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Sep 01, 2020
Volume
13
Issue
9
Pages
2401–2406
Identifiers
PMID: 33042351
PMCID: PMC7539866
Source
PubMed Central
Keywords
License
Unknown

Abstract

Ovarian yolk sac tumors are common germ cell tumors usually arising in young women. Yolk sac tumors in elderly women are infrequently encountered and most of them are combined with other epithelial tumor components including endometrioid carcinoma or serous carcinoma. Here, we report an extremely rare case of a yolk sac tumor with mucinous tumor and large cell neuroendocrine carcinoma components in a postmenopausal woman, which is the third yolk sac tumor case with a neuroendocrine tumor element in an elderly woman. An 82-year-old female visited our hospital due to abdominal distention. Abdominal computed tomography (CT) demonstrated a solid and cystic mass, measuring about 9.0 cm in the largest diameter. A total hysterectomy with bilateral salpingo-oophorectomy and excisional biopsy of the peritoneal metastatic lesions was performed. Histologic evaluation revealed a malignant ovarian tumor composed of a variety of tumor components, including a yolk sac tumor, a mucinous tumor with multifocal mucinous carcinomatous areas, and a large-cell neuroendocrine carcinoma. After surgery, the patient refused further treatment and the disease recurred in the pelvic peritoneum and a left supraclavicular lymph node nine months later.

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