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Ovarian follicle structure of Zebrafish (Danio rerio Hamilton) after poly(2-ethyl-2-oxazoline) exposure.

Authors
  • Yön, Nazan Deniz
  • Olgun, Uğursoy
  • Akbulut, Cansu
Type
Published Article
Journal
Indian journal of experimental biology
Publication Date
Dec 01, 2016
Volume
54
Issue
12
Pages
829–834
Identifiers
PMID: 30183179
Source
Medline
Language
English
License
Unknown

Abstract

Poly(2-oxazoline)s have been widely known for their biomedical applications. They mimic natural systems and are generally used as liposomes, drug and gene delivery modules and also as pseudopeptides. In this study, effects of different doses (10 and 50 mg/L) of poly(2-ethyl-2-oxazoline) on ovarian follicle ultrastructure of zebrafish were investigated with light and electron microscopy. After five days of administation, ovary tissues were disected and routine histological processes were done. Severe structural deformation at zona radiata, follicular epithelium and outer granulosa cell structure were observed. Edema at follicular epithelium, zona radiata and vitelline envelope stuructures were detected. Dose dependent increase in the number of immature oocytes were seen. Briefly, it was demonstrated that poly(2-ethyl-2-oxazoline) exposure affected oogenesis and caused apoptosis in zebrafish.

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