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Ovarian cancer as a genetic disease.

Authors
  • Lech, Agnieszka
  • Daneva, Teodora
  • Pashova, Shina
  • Gagov, Hristo
  • Crayton, Robert
  • Kukwa, Wojciech
  • Czarnecka, Anna M
  • Szczylik, Cezary
Type
Published Article
Journal
Frontiers in Bioscience
Publisher
Frontiers in BioScience
Publication Date
Jan 01, 2013
Volume
18
Pages
543–563
Identifiers
PMID: 23276941
Source
Medline
License
Unknown

Abstract

Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize some genetic factors involved in the disruption of certain signaling pathways responsible for ovarian tumor transformation and development. Those factors considerably contribute to accurate diagnostics, treatment and prognosis in ovarian cancer.

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