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Outer Membrane Protein‐Coated Nanoparticles as Antibacterial Vaccine Candidates

Authors
  • Anwar, Majid1
  • Muhammad, Faqir1
  • Akhtar, Bushra1
  • Anwar, Muhammad Irfan2
  • Raza, Ahmad3
  • Aleem, Abdul1
  • 1 University of Agriculture Faisalabad,
  • 2 Bahauddin Zakariya University,
  • 3 National Institute for Biotechnology and Genetic Engineering (NIBGE),
Type
Published Article
Journal
International Journal of Peptide Research and Therapeutics
Publisher
Springer-Verlag
Publication Date
Apr 08, 2021
Pages
1–9
Identifiers
DOI: 10.1007/s10989-021-10201-3
PMID: 33846682
PMCID: PMC8027978
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Nanoformulations are novel therapeutic strategies as compared to traditional treatments. The development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative vaccine strategies for modifying the antibacterial immunity. A lot of work has been done in which synthetic nanoparticles are coated with biomimetic cellular membranes for enhancement of biological functions and treatments. Outer membrane protein of bacteria not only act as adjuvant but also contain a large number of immunogenic antigens that play an important role in motivating the native immunity and stimulating the immune responses of the body. Outer membrane protein coating onto the surfaces of synthetic nanoparticles has synergistic effects to produce antibacterial responses. This article reviews the recent improvements related to the bacterial membrane-coated nanoparticles for antibacterial immunization.

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